IJMST 2017 Volume 7 Issue 3
International Journal of Medical Sciences and Technology (IJMST) ISSN:0974-5343
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Comparison of Local Cytokine Expression in Vaginal Secretions of Women with Normal and Abnormal Microbiota. Ossai-Chidi Linus Ndidi, Obunge Orikomaba K and Oboro Ibanabo Laura. IJMST (2017), 7(3):18-24
Comparison of Local Cytokine Expression in Vaginal Secretions of Women with Normal and Abnormal Microbiota
Authors & Affiliation:
Ossai-Chidi Linus Ndidi1, Obunge Orikomaba K2 and Oboro Ibanabo Laura3
1 Research Fellow Department of Haematology, Blood Transfusion and Immunology
2 & 3 Clinical Consultant, Department of Medical Microbiology and Parasitology
University of Port Harcourt Teaching Hospital, Port Harcourt Rivers State, Nigeria
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Cytokines play important roles in the mediation of immune responses locally or systemically in every individual. Knowledge of the local expression of cytokines when there is a deviation from normal to abnormal microbiota in the urogenital tract gives an insight to the extent of the innate immune responses to abnormal microbiota. Bacterial vaginosis (BV) is the most common example of changes in urogenital flora. The concentrations of IL-2, IL-10 and TNF-α in vaginal secretions of women with abnormal microbiota was determined by ELISA techniques. Statistical analysis show significant differences (P < 0.05) in the concentrations of the cytokines of the different groups of the women. There were significantly elevated levels (p < 0.05) of TNF-α and IL-10 in women with BV, when compared those of women with intermediate flora. The results show a predominant local pro-inflammatory response to deviations from normal to abnormal microbiota in the urogenital tract.
Keywords: TNF-α, IL-2, IL-10, Abnormal microbiota, Bacterial vaginosis.